Clinical Trials

Below is a list of active clinical trials worldwide which involve patients with inherited bleeding disorders. The link from each study title will take you to ClinicalTrials.gov which gives you more information about the trial.
To see a list of trials for a particular bleeding disorder use the drop-down list below to select the condition you're interested in. A new window will open up with a list of trials for this condition only.

Epidural Spinal Cord Stimulation for Lower-limb Impairment in Adrenomyeloneuropathy Conditions: Adrenomyeloneuropathy Without Cerebral Involvement Interventions: Procedure: Spinal cord stimulation Sponsors: Third Military Medical University; Beijing Tiantan Hospital; Jingmen No.1 People's Hospital; The 958th Hospital of the Chinese People's Liberation Army Recruiting

Randomized Controlled Multicenter Study Comparing Steroid Therapy Plus Anticoagulants to Steroid Therapy Alone in Deep Venous Thrombosis of Behçet's Syndrome Conditions: Behcet Syndrome Interventions: Drug: Corticosteroids + Rivaroxaban; Drug: Corticosteroids alone Sponsors: Assistance Publique - Hôpitaux de Paris Not yet recruiting

Examination of Physiotherapists' Knowledge, Awareness and Competence on Physical Activity and Exercise in Hemophilia Patients Conditions: Hemophilia Sponsors: Gulhane School of Medicine Recruiting

An Open-label Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Immunogenicity of SKP-0141 for the Treatment and Prophylaxis in Severe Hemophilia a Patients Conditions: Hemophilia A, Severe Interventions: Biological: SKP-0141 Sponsors: SK Plasma Co., Ltd. Not yet recruiting

Validation of the EQ-5D-Y-3L and EQ-5D-Y-5L for Paediatric Patients in China Conditions: Quality of Life (QOL); Patient-Reported Outcome Measures (PROMs); Pneumonia Childhood; Neuroblastoma (NB); Wilms Tumour; Immune Thrombocytopenic Purpura ( ITP ) Sponsors: RenJi Hospital; The EuroQol Research Foundation; Guizhou Provincial People's Hospital; Guizhou Medical University; The Children's Hospital of Zhejiang University School of Medicine; The Affiliated Hospital Of Guizhou Medical University Not yet recruiting

An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment Conditions: Von Willebrand Disease, Type 3 Interventions: Drug: Von Willebrand Factor Concentrates; Drug: Von Willebrand Factor Concentrates and Factor VIII Concentrates; Drug: Factor VIII Concentrates; Drug: Recombinant Activated Factor VII; Drug: Activated Prothrombin Complex Concentrate Sponsors: Hoffmann-La Roche Not yet recruiting

Synovial Proliferation on Routine Ultrasound: Active or Inactive? Conditions: Haemophilia; Hemophilia a; Hemophilia B Interventions: Other: Ultrasound imaging Sponsors: Van Creveldkliniek Not yet recruiting

Comparison of Saliva Biomarkers in Two Different Geographical Regions of Turkey Conditions: Saliva; Cortisol; Smoking, Tobacco; Periodontal Bone Loss; Periodontal Disease; Periodontal Therapy Interventions: Procedure: Non-Surgical Intervention; Diagnostic Test: Saliva Collection (Baseline); Other: Probing; Diagnostic Test: Saliva Collection (After treatment) Sponsors: Karabuk University; Ataturk University; Ankara University Completed

Post-marketing Surveillance (Special Use-results Surveillance) on Treatment With Alhemo Conditions: Haemophilia A, Haemophilia B Interventions: Drug: Concizumab Sponsors: Novo Nordisk A/S Not yet recruiting

Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal Diversion Conditions: Colorectal Anastomosis; Endometrial; Anastomotic Leak Rectum; Ulcerative Colitis (Disorder); Adenomatous Polyposis Coli, Familial; Crohn Disease; Digestive Cancers; Protectomy Interventions: Other: preoperative stoma identification and education Sponsors: Assistance Publique Hopitaux De Marseille Not yet recruiting

BCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases Conditions: Systemic Lupus Erythematosus; Inflammatory Myopathy; Systemic Sclerosis (SSc); ANCA-associated Vasculitis; IgG4-Related Diseases; Antiphospholipid Syndrome; Acquired Thrombotic Thrombocytopenic Purpura; Behcet Disease; Sjogren Syndrome Interventions: Drug: BCMA-CD19 CAR-T therapy Sponsors: Peking University People's Hospital Recruiting

A Study to Investigate the Course of Synovial Hypertrophy in Patients With Haemophilia A on Efanesoctocog Alfa Prophylaxis Conditions: Haemophilia A (Moderate or Severe); Hemophilia, Classic; Haemophilia; Hemophilia; Classic Hemophilia; Synovial Hypertrophy Interventions: Drug: Efanesoctocog alfa Sponsors: Swedish Orphan Biovitrum; PSI CRO Recruiting

Early Genomic Testing for Inherited Bleeding Disorders Conditions: Bleeding Disorder Interventions: Genetic: Genetic testing for inherited bleeding disorders Sponsors: Kingston Health Sciences Centre; Unity Health Toronto; The Ottawa Hospital Not yet recruiting

KN057 Multiple Dose Study in Patients with Hemophilia a or Hemophilia B with or Without Inhibitors Conditions: Hemophilia a and B Interventions: Drug: KN057 Sponsors: Suzhou Alphamab Co., Ltd. Not yet recruiting

Evaluation of Voice in Behcet's Conditions: Behcet Disease Interventions: Other: 1-Laryngyscopic examination 2-Acoustic analysis Sponsors: Minia University Not yet recruiting

Assessing Different FVIII Doses and Frequencies in Immune Tolerance Induction (ITI) with ADVATE Among Hemophilia a Boys with Inhibitor (INITIATE Study) Conditions: Hemophilia a with Inhibitor Interventions: Drug: Advate®; Drug: Advate®; Drug: Advate®; Drug: Advate®; Drug: Advate® Sponsors: Runhui WU Recruiting

A Study Assessing HMB-002 in Participants With Von Willebrand Disease Conditions: Von Willebrand Disease (VWD); Von Willebrand Disease (VWD), Type 1 Interventions: Drug: HMB-002 (Part A); Drug: HMB-002 (Part B) Sponsors: Hemab ApS Recruiting

Comparison of Upper Extremity Functional Performance in Hemophilic and Healthy Children Conditions: Hemophilia; Upper Extremity; Strength; Performance; Children Sponsors: Hacettepe University Enrolling by invitation

Recombinant Single-chain Factor VIII (rVIII-SingleChain) in Chinese Participants With Hemophilia A Previously Treated With FVIII Products Conditions: Congenital Hemophilia A Interventions: Biological: Recombinant single-chain factor VIII (rVIII-SingleChain) Sponsors: CSL Behring Recruiting

Manual Therapy in Hemophilic Arthropathy of the Ankle Conditions: Hemophilia A Interventions: Other: Manual Therapy; Other: Placebo Sponsors: Investigación en Hemofilia y Fisioterapia Recruiting

ATHNdataset Registry Conditions: Hemophilia; Thrombosis; Hemophilia A; Hemophilia B; Sickle Cell Disease; Glanzmann Thrombasthenia; Bleeding Disorder; Blood Disorder; Von Willebrand Diseases Sponsors: American Thrombosis and Hemostasis Network Enrolling by invitation

To Evaluate the Clinical Study of GS1191-0445 Injection in the Treatment of Hemophilia a Conditions: Hemophilia a Interventions: Drug: GS1191-0445 injection Sponsors: Gritgen Therapeutics Co., Ltd. Not yet recruiting

Cartilage Biomarkers and HEAD-US Score in Severe Hemophilia A Patients Receiving FVIII Prophylaxis Conditions: Hemophilia A Interventions: Diagnostic Test: HEAD-US; Diagnostic Test: Urinary carboxy-terminal cross linked telopeptide of type II collagen; Diagnostic Test: Inflammatory markers Sponsors: Chulalongkorn University Enrolling by invitation